Marat Ospanov West Kazakhstan Medical University
Contract with the Ministry of Education and Science of the Republic of Kazakhstan / No. 178/30-22-24 from 18.10.2022
Name of the priority direction of science development
5 – Life Science and Health
Key words , characterizing the industry and direction of the research
SARS-CoV-2, QazVac, SputnikV, humoral immune response ,cellular immunity , post COVID 19 condition
Years of implementation
01.07.2022-31.12.2024, 30 months
Research goal
To research the effect of vaccination with the domestic vaccine QazVac on the indicators of cellular and humoral immunity in patients with a post COVID 19 condition among the population of Western Kazakhstan in order to identify risk factors for its occurrence.
Project objectives
1.To study the prevalence and epidemiological features of the development of the post COVID condition, depending on the status of vaccination, the level of awareness and adherence to vaccination.
2.To study the features of humoral and cellular immunity in patients with post-COVID syndrome, depending on the status of vaccination and in the control group, vaccinated with the domestic vaccine QazVac.
3.To study the clinical and laboratory indicators of the manifestations of the post COVID 19 condition in patients after vaccination with the domestic QazVac vaccine, Sputnik V vaccine and unvaccinated.
4.Identify risk factors for post-COVID 19 conditions depending on vaccine status and develop a risk map.
Relevance
After an acute infection with COVID 19, some patients still have health problems. To date, little is known about specific T-cell responses and antibodies in patients with a post-COVID 19 condition, and risk factors contributing to the onset of a post-COVID 19 condition have not been identified.
In this regard, within the framework of a scientific project, the prevalence of conditions after COVID 19 will be studied, the level of commitment of the population of Aktobe to vaccination against COVID 19 and confidence in the domestic vaccine QazVac will be determined. The research will study the humoral and cellular components of natural and post-vaccination immunity in 3 categories of patients: patients with post-COVID syndrome, vaccinated with the domestic QazVac vaccine, SputnikV vaccine and those who have not been vaccinated. A control study of immunoglobulins and lymphocyte populations will be carried out in individuals after vaccination with the domestic QazVac vaccine.
A comparative analysis of clinical, laboratory and immunological parameters (immunoglobulins and lymphocyte populations), as well as in healthy individuals who received the QazVac vaccine, will be carried out.
Expected results
The results of epidemiological studies will be the identification of the level of public commitment to vaccination against COVID 19, as well as confidence in the domestic vaccine. The main sources of information that inspire confidence among the population to understand the need for vaccination will be identified. A web questionnaire will be developed, an author’s certificate will be obtained. The obtained results of epidemiological studies will make it possible to substantiate recommendations to general practitioners to work with the population on vaccination. The online questionnaire will be in demand by public health specialists to identify awareness and commitment of various strata to vaccination.
The result of the study of clinical and immunological changes (conditions, deviations) that occurred in patients with a post-covid condition: without vaccination, vaccinated with QazVac vaccine and SputnikV vaccine. A risk map will be developed depending on the vaccination status and an author’s certificate will be obtained.
3 undergraduates will be trained.
It is planned to publish articles in foreign peer-reviewed scientific journals, presumably:
– 2 articles will be published in scientific publications in the scientific direction of the project, indexed in the Web of Science and Scopus databases, with a CiteScore percentile in the Scopus database of at least 35 (thirty-five);
– 3 articles or reviews will be published in a peer-reviewed foreign or domestic publication recommended by the CQAFSHE; (Committee for Quality Assurance in the Field of Science and Higher Education)
It is planned to participate in international conferences / congresses with the publication of abstracts – 3. Acts of implementation in practical healthcare 2 will be issued
The final product of the study is to write a monograph, which will present the results on the topic under study, namely the epidemiological, clinical and immunological features of post-covid conditions in the population of Aktobe.
Results achieved in 2022
A web-questionnaire was developed in 2 languages and a copyright certificate was received. The participant’s IRC and informed consent forms were developed and replicated, the researcher’s magazines and brochures (instructions) were developed. Members of the research group were trained to conduct the study, fill out documentation and work with the database. Questionnaires are being sent out among the population of Aktobe, 817 questionnaires have been collected. A database of patients with post-covid syndrome is being studied in 3 polyclinics in Aktobe for the selection of patients and people in the control group for the study.
Supervisor
Urazaeva T.Saltanat – Candidate of Medical Sciences, Associate Professor, Head of the Department of Epidemiology.
She has about 100 scientific publications, of which 4 are published in scientific journals indexed in the Web of Science and Scopus databases; author of 8 textbooks.
Research interests: epidemiology of infectious and non-infectious diseases, vaccinology. She was the head of the scientific and technical program funded by the university – “Studying the epidemiological patterns of the course of anthroponotic infectious diseases among adolescents and adults in the Aktobe region” (2016-2017) and a participant in the scientific and technical program funded by the Ministry of Health of the Republic of Kazakhstan “National program for the introduction of personalized and preventive medicine in Republic of Kazakhstan” 2021-2023 (IRN OR12165486)
Urazaeva S.T. – Scopus Researcher ID-57208062042
Urazaeva S.T. – Web of Science Researcher ID – ABF-6482-2021
TRT
- Saltanat T.Urazayeva, Candidate of Medical Sciences, Associate Professor, Head of the Department of Epidemiology of NJSC “WKMU named after Marat Ospanov” – Leading Researcher, Project Manager;
https://orcid.org/0000-0002-4773-0807;
- Kurmangalieva S.Saule , Candidate of Medical Sciences Head of the Department of Microbiology, Virology, Immunology of the NJSC “WKMU named after Marat Ospanov”– senior researcher of the project;
https://orcid.org/0000-0002-9502-1490;
- Tusupkalieva Sh.Kymbat, Candidate of Medical Sciences, docent of the Department of Epidemiology of the NJSC “WKMU named after Marat Ospanov” – senior researcher of the project;
https://orcid.org/0000-0002-6980-378X;
- Seitmaganbetova A.Nazgul, Candidate of Medical Sciences, Associate Professor of the Department of Propaedeutics of Internal Diseases of the NJSC “WKMU named after Marat Ospanov” – senior researcher of the project. https://orcid.org//0000-0002-7718-4464;
- Begalin Toleukhan, Candidate of Medical Sciences, Senior teacher of the Department of Epidemiology of the NJSC “WKMU named after Marat Ospanov” – researcher of the project;
https://orcid.org//0000-0003-2338-6236;
- Urazaeva B.Aisha, PhD, Acting Associate Professor of the Department of Epidemiology of the NJSC “WKMU named after Marat Ospanov” – senior researcher of the project;
https://orcid.org/0000-0001-5978-2957;
- Tashimova K.Zhuldyz, Master МВА, Senior lecturer of the Department of Epidemiology of the NJSC “WKMU named after Marat Ospanov” – researcher of the project;
https://orcid.org//0000-0001-7708-2049;
- Baktikulova V.Kristina, laboratory doctor at the Medical Center of the NJSC “WKMU named after Marat Ospanov” – junior researcher of the project; https://orcid.org//0000-0003-1806-1058;
- Begalina T.Dana, Assistant of the Department of General Medical Practice №2 of the NJSC “WKMU named after Marat Ospanov” – junior researcher of the project;
https://orcid.org//0000-0003-0162-5005
- Zhumagalieva K.Saltanat , Master of Technical Sciences, Junior Researcher of the Department of Management of Research Activities of the NJSC”WKMU named after Marat Ospanov” – junior researcher of the project;
